Biochemistry Department

Xuan Liu

Dr. Xuan Liu

Xuan Liu
Professor of Biochemistry

Biomedical Research
Molecular Biology


Liu Research Group

Selected Publications
  • Freeman, D.J., A.G. Li, G. Wei, H.-H. Li, R. Lesche, A.D. Whale, H. Martinez-Diaz, N. Rozengurt, X. Liu* and H. Wu*. (2003). PTEN tumor suppressor regulates p53 protein levels and activity through both phosphatase-dependent and -independent mechanisms. Cancer Cell 3:117-130 *corresponding authors
  • Li, H.-H., A.G. Li, H.M. Sheppard and X. Liu. (2004). Phosphorylation on Thr55 by TAF1 mediates degradation of p53: a role for TAF1 in cell cycle regulation. Molecular Cell 13:867-878
  • Wei, G., A.G. Li and X. Liu. (2005). Insights into selective activation of p53 DNA binding by c-Abl. Journal of Biological Chemistry 280:12271-12278
  • Li, A.G., L.G. Piluso, X. Cai, G. Wei, W.R. Sellers and X. Liu. (2006). Mechanistic insights into maintenance of high p53 acetylation by PTEN. Molecular Cell 23:575-587
  • Li, H.-H., X. Cai, G.P. Shouse, L.G. Piluso and X. Liu. (2007). A specific PP2A regulatory subunit, B56γ, mediates DNA damage-induced dephosphorylation of p53 at Thr55. EMBO Journal 26:402-411
  • Li, A.G., L.G. Piluso, X. Cai, B.J. Gadd, A.G. Ladurner and X. Liu. (2007). An acetylation switch in p53 mediates holo-TFIID recruitment. Molecular Cell 28:408-421
  • Shouse, G.P., X. Cai and X. Liu. (2008). Serine 15 phosphorylation of p53 directs its interaction with B56g and the tumor suppressor activity of B56γ-specific PP2A, Molecular Cellular Biology, 28:448-456
  • Cai, X. and X. Liu. (2008). Inhibition of Thr55 phosphorylation restores p53 nuclear localization and sensitizes cancer cells to DNA damage. Proc. Natl. Acad. Sci. USA. 105,16958-63
  • Shouse, G.P., Y. Nobumori and X. Liu. (2010). A B56γ mutation in lung cancer disrupts the p53-dependent tumor suppressor function of protein phosphatase 2A. Oncogene 29, 3933-3941
  • Shouse, G.P., Y. Nobumori and X. Liu. (2011). ATM-mediated phosphorylation stabilizes B56γ and activates tumor suppressive function of B56γ-specific PP2A. Oncogene 30, 3755-3765
  • Nobumori, Y., G.P. Shouse, L. Fan and X. Liu. (2012). HEAT repeat 1 motif is required for B56γ-containing protein phosphatase 2A (B56g-PP2A) holoenzyme assembly and tumor suppressive function. Journal of Biological Chemistry 287, 11030-36
  • Nobumori, Y., G.P. Shouse, Y. Wu, K.J. Lee, B. Shen and X. Liu. (2013). B56γ tumor-associated mutations provide new mechanisms for B56g-PP2A tumor suppressor activity. Molecular Cancer Research 11, 995-1003
  • Wu, Y., J.C. Lin, L.G. Piluso, J.M. Dhahbi, S. Bobadilla, S.R. Spindler, and X. Liu. (2014). Phosphorylation of p53 by TAF1 inactivates p53-dependent transcription in the DNA damage response. Molecular Cell 53, 63-74
  • Wu, Y., H. Zhou, K. Wu, S.K. Lee, R. Li and X. Liu. (2014). PTEN phosphorylation and nuclear export mediate free fatty acid-induced oxidative stress. Antioxidants & Redox Signaling, in press


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