The Department of Biochemistry's weekly BCH 252 seminar series is presented this week by:

Linfeng Gao, ETOX Graduate Student, UC Riverside 

Seminar Title: "Study of allosteric regulation and substrate recognition in mammalian DNA methylation"

Abstract: In mammalian epigenetic regulation, DNA methylation is essential for controlling transcription silencing, X chromosome inactivation, genomic imprinting and stability. During gametogenesis and early embryonic development, the DNA methylation pattern is established by de novo DNA methyltransferases DNMT3A and DNMT3B, and is further maintained by DNMT1 with its regulation partner UHRF1 during DNA replication along each cell cycle. Our studies provided structural basis and molecular mechanism of allosteric regulation of UHRF1 associating histone modification and DNMT3B-mediated DNA methylation, shedding light onto understanding how inter/intra-molecular interaction plays an important role in mammalian epigenetic regulation.