The Department of Biochemistry's weekly BCH 252 seminar series is presented this week by:

Adam Godzik, Professor of Biomedical Sciences, School of Medicine UC Riverside 

Seminar Title: "Structural systems biology – understanding how networks work (and how they break) on the molecular level"

Abstract: Progress in experimental protein structure determination and advances in modeling and distant homology recognition now allows us to model, at least on the low resolution level, the 3D structure a majority of protein in actively studied organisms (~80% for model bacteria, ~60% for average bacteria and model eukaryotic organisms, ~40-50% for average eukaryotic organism).At the same time, disease genomics gives us thousands of data points of relations between germline and somatic mutations and disease phenotypes. This gives us a new perspective to understand biological pathways and networks. I would illustrate the concept of structural systems biology on examples from bacterial metabolism, drug resistance, but also on understanding cancer and autoimmune diseases.

Faculty Host: Dr. Daniel Gallie; daniel.gallie@ucr.edu